Investigators Lincoln Rhyme and Amelia Sachs are recruited to track down a cargo ship carrying two dozen illegal Chinese immigrants, as well as the notorious human smuggler and killer known only as the Ghost. But when the capture goes disastrously wrong, Lincoln and Amelia find themselves in a race to stop the Ghost before he can track down and murder the two surviving families who have vanished deep into the labyrinthine world of New York City's Chinese community.
Over the next forty-eight hours the Ghost ruthlessly hunts for the families while Rhyme struggles desperately to find them first. Meanwhile, Sachs pursues a very different kind of policework - forming a connection with one of the immigrants that may have far reaching consequences for her relationship with her partner and lover, Lincoln Rhyme.